Skincare

Can you use niacinamide and vitamin C together?

By the LÉRA team · · 2 min read

A tube of LÉRA Red Tea Mask beaded with water droplets

The short answer

Yes. The idea that niacinamide and vitamin C cancel each other out comes from old laboratory work using unstable forms of the ingredients under conditions, including heat, that don't match how skincare is used. Modern products, especially those with stabilized vitamin C, combine them routinely. If your skin is sensitive, introduce one at a time.

Where the warning came from

The worry traces back to research from decades ago, in which pure ascorbic acid and niacinamide were combined in conditions that don't match how skincare is made or worn, including heat. In those conditions they could react with each other. The finding spread as "never mix them" long after formulas moved on.

Why it doesn't apply to modern skincare

Many products now use stabilized vitamin C derivatives, such as 3-O-ethyl ascorbic acid, which are designed to resist breaking down. And at room temperature, on your face, the two don't react in any way that matters. Plenty of well-made products put them in the same formula on purpose.

What each one does

  • Niacinamide (vitamin B3) is used to support the skin's barrier and help skin look more even.
  • Vitamin C is an antioxidant used to help skin look brighter.

How to use them together

  1. Layer the thinnest product first and the thickest last.
  2. If you're new to either, introduce one at a time, a week or two apart, so you know which your skin is reacting to if it does.
  3. Wear sunscreen in the day. It protects the results of everything else.

A product that already combines them

Our Red Tea Mask pairs 2.3% niacinamide with 3-O-ethyl ascorbic acid, a stabilized vitamin C, in a hydrating mask with three forms of hyaluronic acid, centella asiatica and red and green tea extracts. It rinses off, so it's an easy way to use both without changing the rest of your routine. See how to use a hydrating face mask.

Questions people ask

Does niacinamide cancel out vitamin C?

No, not in modern skincare. The old concern came from lab conditions that don't apply to products used at room temperature.

Should I use vitamin C or niacinamide first?

Go from thinnest to thickest. If both are serums, either order works; give the first a minute to settle.

Can I use niacinamide and vitamin C every day?

Many people do. If your skin gets red or stings, cut back to every other day or use them at different times of day.

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